Fig. 2
From: The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration
The endosomal–lysosomal system and AD. (i) endosomal enlargement, Rab5 overexpression and Aß accumulation; (ii) dysregulated endosomal-lysosomal acidification, pH elevation and tau aggregation; (iii) dysfunctional ESCRT complexes, defective autophagy and accumulation of intraluminal ubiquitinated proteins; (iv) defects of retromer: reduction of Vps26, Vps35 and SorLA disrupts the trafficking and processing of APP