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Table 2 The advantages and disadvantages of using BFCNs as donor cells in the stem cell-based approaches for AD

From: The promise of stem cells in the therapy of Alzheimer’s disease

Advantages Disadvantages
Subtype-specific replacing the lost endogenous BFCNs in basal forebrain The standard preparation of homogeneous human BFCN progenitors
Repairing the dysfunctions of basal forebrain cholinergic system by releasing acetylcholine, neurotrophic factors or cytokines The efficient cholinergic specificaiton of BFCN progenitors, and long term survival of cholinergic derivatives in vivo
Functionally integrating into the endogenous basal forebrain neural circuitries The disabilities of lone-distance innervation from the basal forebrain to hippocampus and cortex
Rescuing the innervation track along the host cholinergic projections through out the basal forebrain The uneven and patchy migration through the basal forebrain to hippocampus and cortex