Table 1 The reported stem cell-based therapies in AD animal models
From: The promise of stem cells in the therapy of Alzheimer’s disease
Donor cells | AD models | Graft site | Behavior recovery | Possible mechanism | Key refs. |
|---|---|---|---|---|---|
Mouse astrocytes | ApdE9 transgeneic mouse | Hippocampus | Not known | Aβ deposits clearing | [9] |
Mouse adult NSCs | 3xTg transgeneic mouse | Hippocampus | Learning and memory | BDNF induction | [5] |
Mouse cholinergic motor neuron precursors | Rat with NBM lesion | NBM | memory recovery | Not Known | [6] |
Human UCB-MSCs | Not known | Hippocampus | Memory | Reducing neuronal apoptosis | [7] |
Mouse BM-MSCs | APP/PS1 transgeneic mouse | Hippocampus | Memory | reducing Aβ deposits | ([8] |
Human iPSC-derived motor neuron precursors | PDAPP transgeneic mouse | Hippocampus | Spatial Memory | Not Known | [12] |