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Table 1 The reported stem cell-based therapies in AD animal models

From: The promise of stem cells in the therapy of Alzheimer’s disease

Donor cells AD models Graft site Behavior recovery Possible mechanism Key refs.
Mouse astrocytes ApdE9 transgeneic mouse Hippocampus Not known Aβ deposits clearing [9]
Mouse adult NSCs 3xTg transgeneic mouse Hippocampus Learning and memory BDNF induction [5]
Mouse cholinergic motor neuron precursors Rat with NBM lesion NBM memory recovery Not Known [6]
Human UCB-MSCs Not known Hippocampus Memory Reducing neuronal apoptosis [7]
Mouse BM-MSCs APP/PS1 transgeneic mouse Hippocampus Memory reducing Aβ deposits ([8]
Human iPSC-derived motor neuron precursors PDAPP transgeneic mouse Hippocampus Spatial Memory Not Known [12]
  1. NSCs, neural stem cells, NBM, nucleus basalis of Meynert, UCB-MSCs, umbilical cord blood-derived mesenchymal stem cells, BM-MSCs, bone marrow-derived mesenchymal stem cells, PDAPP, PDGF promoter driven amyloid precursor protein transgenic mice.