Table 4 Examples of existing drugs used to treat non-motor symptoms of PD
Non-motor symptom | Example | Status |
|---|---|---|
Bladder dysfunction | Anticholinergics - oxybutinin | Marketed |
Depression/anxiety | SSRI - paroxetine | Marketed |
SNRI - venlafaxine | Marketed | |
Tricyclic antidepressants – nortryptyline, desipamine | Marketed | |
Dopamine agonist - pramipexole | Marketed | |
Psychosis | Atypical antipsychotics – quetiapine | Marketed |
5-HT antagonist - primavanserin | Approved in USA | |
Dementia | Cholinesterase inhibitors - rivastigmine | Marketed |
Sleep disturbance - insomnia | Hypnotic - zolpidem | Marketed |
Excessive daytime somnolence | Modafinil | Marketed |