Table 1 Examples of existing and novel approaches to the treatment of dyskinesia
Drug class | Example | Status |
|---|---|---|
Glutamate antagonists | ||
Non-specific NMDA | IR – amantadine | Marketed |
CR - amantadine | Clinical trials | |
NR2B | Experimental | |
AMPA | Talampanel, perampanel | Clinical trials |
mGluR5 | Mavoglurant | Clinical trials |
Other pharmacological classes | ||
5-HT 1a/1b agonists | - | Experimental |
5-HT 2c antagonists | - | Experimental |
Adrenergic antagonists | Fipamezole | Experimental |
Opioid agonists and antagonists | - | Experimental |
Cannabinoid agonists | - | Experimental |
Nicotinic agonists | - | Experimental |
Anticonvulsants | Levetiracetam | Clinical trials |