Skip to main content

Table 1 Study characteristics of pre-clinical studies on rodent models of Parkinson’s disease

From: The effects of exercise on cognition in Parkinson’s disease: a systematic review

Authors

Study title

Subjects

Intervention

Goes et al., 2013 [21]

Neuroprotective effects of swimming training in a mouse model of Parkinson’s disease induced by 6-hydroxydopamine

• 2 groups (n = 20 each): 6-OHDA, saline

• 20–60 min/day, 5 days/week for 4 weeks

• 2 treatment cohorts (n = 10 each): swimming training, no exercise

• Starting 4 days after toxin administration

Gorton et al., 2010 [17]

Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse

• 2 groups (n = 24 each): MPTP, saline

• Up to 1 hr/day, 5 days/week for 4 weeks

• 3 treatment cohorts (n = 8/group): forced exercise, voluntary exercise, no exercise

• Starting 5 days after toxin administration

Tajiri et al., 2010 [18]

Exercise exerts neuroprotective effects on Parkinson's disease model of rats

• 1 group (n = 60): 6-OHDA

• 30 min/day, 5 days/week for 4 weeks

• 2 treatment cohorts (n = 30 each): forced exercise, no exercise

• Starting 1 day after toxin administration

Aguiar et al., 2009 [19]

Physical exercise improves motor and short-term social memory deficits in reserpinized rats

• 4 groups (n = 24 each): high/low dose reserpine or high/low dose saline

• 20–25 min/day, 5 days/week for 4 weeks

• Starting 4 weeks before toxin administration

• 3 treatment cohorts± (n = 8/group):forced exercise, voluntary exercise, no exercise

Pothakos et al., 2009 [20]

Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration

• 2 groups (n = 29 each): probenecid/MPTP (model of chronic PD), probenecid only

• 40 min/day, 5 days/week for 8–12 weeks

• Starting 1 week before, 5 weeks during, 8–12 weeks after toxin administration

• 2 treatment cohorts (n = 5-10/group): forced endurance exercise, no exercise – for probenicid/MPTP group only

Fisher et al., 2004 [16]

Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- lesioned mouse basal ganglia

• 2 groups (n = 60 each): MPTP, saline

• Up to 2x 30 min/day, 5 days/week for 4 weeks

• 2 treatment cohorts (n = 20/group): forced exercise, no exercise*

• Starting 4 days after toxin administration

  1. ±Only rats able to maintain a forward position on the treadmill were assigned to the treadmill exercise group.
  2. *Only rats able to maintain a forward position on the treadmill were randomized to either exercise or no exercise cohort.