From: The effects of exercise on cognition in Parkinson’s disease: a systematic review
Authors | Study title | Subjects | Intervention |
---|---|---|---|
Goes et al., 2013 [21] | Neuroprotective effects of swimming training in a mouse model of Parkinson’s disease induced by 6-hydroxydopamine | • 2 groups (n = 20 each): 6-OHDA, saline | • 20–60 min/day, 5 days/week for 4 weeks |
• 2 treatment cohorts (n = 10 each): swimming training, no exercise | |||
• Starting 4 days after toxin administration | |||
Gorton et al., 2010 [17] | Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse | • 2 groups (n = 24 each): MPTP, saline | • Up to 1 hr/day, 5 days/week for 4 weeks |
• 3 treatment cohorts (n = 8/group): forced exercise, voluntary exercise, no exercise | |||
• Starting 5 days after toxin administration | |||
Tajiri et al., 2010 [18] | Exercise exerts neuroprotective effects on Parkinson's disease model of rats | • 1 group (n = 60): 6-OHDA | • 30 min/day, 5 days/week for 4 weeks |
• 2 treatment cohorts (n = 30 each): forced exercise, no exercise | |||
• Starting 1 day after toxin administration | |||
Aguiar et al., 2009 [19] | Physical exercise improves motor and short-term social memory deficits in reserpinized rats | • 4 groups (n = 24 each): high/low dose reserpine or high/low dose saline | • 20–25 min/day, 5 days/week for 4 weeks |
• Starting 4 weeks before toxin administration | |||
• 3 treatment cohorts± (n = 8/group):forced exercise, voluntary exercise, no exercise | |||
Pothakos et al., 2009 [20] | Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration | • 2 groups (n = 29 each): probenecid/MPTP (model of chronic PD), probenecid only | • 40 min/day, 5 days/week for 8–12 weeks |
• Starting 1 week before, 5 weeks during, 8–12 weeks after toxin administration | |||
• 2 treatment cohorts (n = 5-10/group): forced endurance exercise, no exercise – for probenicid/MPTP group only | |||
Fisher et al., 2004 [16] | Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- lesioned mouse basal ganglia | • 2 groups (n = 60 each): MPTP, saline | • Up to 2x 30 min/day, 5 days/week for 4 weeks |
• 2 treatment cohorts (n = 20/group): forced exercise, no exercise* | |||
• Starting 4 days after toxin administration |