Figure 1
From: Regulation of Myelination in the Central Nervous System by Nuclear Lamin B1 and Non-coding RNAs
Model for the mechanism of miR-23a in regulating myelination. MiR-23a enhances 2700046G09Rik and represses PTEN and lamin B1 in oligodendroglia. Lamin B1 overexpression reduces the occupancy of YY1 on Plp promoter, decreases transcription of myelin genes, and causes mislocalization of myelin proteins. 2700046G09Rik interacts with and stabilizes miR-23a. In addition, 2700046G09Rik re-compartments and alters miR-23a sub-cellular localization, which further enhances repressive effects of miR-23a on PTEN. Less PTEN in antagonizing PI3K activity leads to AKT activation which then results in myelination. miR-23a represses lamin B1 leading to increased myelination.