Figure 1

Selective loss of ALDH1A1-positive subtype nigrostriatal DA neurons in PD. Cartoons illustrate the distribution of ALDH1A1–negative (ALDH1A1⁻, red) and –positive (ALDH1A1⁺, blue) DA neurons, as well as ALDH1A1⁺ neurons that lose ALDH1A1 expression (ALDH1A1⁺➔ ALDH1A1⁻, red with blue outline) in the SNpc of non-pathology control (NPC) and PD brains with mild and severe depigmentation. VL: ventral lateral, VM: ventral medial.