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Table 1 Differences between enrolled patients with and without WO and dyskinesia

From: Prevalence of wearing-off and dyskinesia among the patients with Parkinson’s disease on levodopa therapy: a multi-center registry survey in mainland China

Items WO Dyskinesia
  With (n = 724) Without (n = 834) P value With (n = 160) Without (n = 1398) P value
Age, years    <.0001    0.0016
 Mean ± SD 63.8 ± 9.6 66.5 ± 9.3   63.0 ± 9.5 65.5 ± 9.5  
n (missing) 710(14) 815(19)   156(4) 1369(29)  
Gender, Female    0.0422    0.1959
n (%) 347(47.9) 356(42.8)   80(50.0) 623(44.6)  
n (missing) 724(0) 832(2)   160(0) 1396(2)  
Height, cm    0.2230    0.2203
 Mean ± SD 164.1 ± 7.8 164.6 ± 7.7   163.6 ± 8.3 164.4 ± 7.7  
n (missing) 717(7) 826(8)   157(3) 1386(12)  
Weight, kg    0.0090    <.0001
 Mean ± SD 60.9 ± 11.1 62.3 ± 10.7   58.46 ± 10.12 62.01 ± 10.91  
n (missing) 720(4) 826(8)   158(2) 1388(10)  
Onset age, years    <.0001    <.0001
 Mean ± SD 57.3 ± 9.9 62.3 ± 9.5   54.9 ± 9.9 60.5 ± 9.9  
n (missing) 711(13) 783(51)   156(4) 1338(60)  
Disease duration, years    <.0001    <.0001
 Mean ± SD 6.7 ± 4.4 4.2 ± 3.7   8.2 ± 5.5 5.1 ± 4.0  
n (missing) 713(11) 796(38)   155(5) 1354(44)  
UPDRS-III*    <.0001    0.1678
 Mean ± SD 19.0 ± 8.4 15.6 ± 6.7   18.8 ± 9.1 17.8 ± 7.9  
n (missing) 724(0) 327(0)   160(0) 891(0)  
L-dopa duration, years    <.0001    <.0001
 Mean ± SD 5.1 ± 3.9 3.3 ± 3.5   5.9 ± 4.7 3.9 ± 3.7  
n (missing) 703(21) 785(49)   151(9) 1337(61)  
L-dopa dosage    <.0001    <.0001
 Mean ± SD 478.5 ± 247.0 355.4 ± 191.5   581.7 ± 311.4 393.8 ± 207.7  
n (missing) 724(0) 834(0)   160(0) 1398(0)  
≤400 mg/d n (%) 359(37.2) 607(62.8) <.0001 52(5.4) 914(94.6) <.0001
400-600 mg/d n (%) 234(56.5) 180(43.5)   54(13.0) 360(87.0)  
>600 mg/d n (%) 131(73.6) 47(26.4)   54(30.3) 124(69.7)  
LED    <.0001    <.0001
 Mean ± SD 558.4 ± 281.7 414.4 ± 216.0   707.8 ± 336.9 455.4 ± 234.9  
n (missing) 724(0) 834(0)   160(0) 1398(0)  
ADL*    <.0001    <.0001
 Mean ± SD 28.4 ± 12.9 21.0 ± 9.6   31.3 ± 13.6 25.1 ± 12.0  
n (missing) 721(3) 326(1)   160(0) 887(4)  
Medications for PD, n (%)
 Levodopa-benserazide 647(89.4) 682(81.8) <.0001 136(85.0) 1193(85.3) 0.9094
 Levodopa-carbidopa 285(39.4) 253(30.3) 0.0002 87(54.4) 451(32.3) <.0001
 Pramipexole 245(33.8) 266(31.9) 0.4147 58(36.3) 453(32.4) 0.3262
 Piribedil 196(27.1) 168(20.1) 0.0013 66(41.3) 298(21.3) <.0001
 Entacapone 152(21.0) 109(13.1) <.0001 43(26.9) 218(15.6) 0.0003
 Selegiline 17(2.4) 32(3.8) 0.0931 4(2.5) 45(3.2) 0.6216
 Trihexyphenidyl 101(13.9) 114(13.7) 0.8725 17(10.6) 198(14.2) 0.2190
 Amantadine 174(24.0) 182(21.8) 0.3000 46(28.8) 310(22.2) 0.0606
  1. *based on patients with complete CRF; WO Wearing-off, UPDRS Unified Parkinson’s Disease Rating Scale, LED, Levodopa equivalent dosage, ADL Activities of Daily Living.