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Table 1 Deregulated miRNAs in HD

From: In silico analysis of regulatory networks underlines the role of miR-10b-5p and its target BDNF in huntington’s disease

miRNA

NEV Control

NEV HD

foldChange

FDR

Other studies

miR-196a-5p

0.00

19.01

Inf

1.4E-010

[9, 14]

miR-891a

48.39

101.39

2.10

0.00001

-

miR-10b-5p

1011.52

30689.38

30.34

0.00003

[9]

miR-4645-3p

3.66

9.44

2.58

0.0001

-

miR-1247-5p

135.61

309.04

2.28

0.0004

[9]

miR-10b-3p

0.00

5.28

Inf

0.0026

-

miR-363-3p

2239.63

3274.71

1.46

0.0033

[8]

miR-30a-3p

5223.90

6943.31

1.33

0.0048

[8]

miR-125b-2-3p

17177.77

20740.93

1.21

0.0052

-

miR-615-3p

0.00

5.45

Inf

0.0065

[9]

miR-196b-5p

1.09

10.17

9.33

0.0134

[9]

miR-127-3p

175251.70

224611.39

1.28

0.0194

-

miR-208b

75.76

112.90

1.49

0.0217

-

miR-302a-5p

2.67

6.93

2.60

0.0451

-

miR-2682-5p

212.76

299.86

1.41

0.0451

-

miR-30a-5p

171969.53

228298.92

1.33

0.0451

[8]

miR-770-5p

333.36

445.55

1.34

0.0451

-

miR-130a-3p

4740.57

6385.28

1.35

0.0451

-

miR-92b-5p

40.62

57.17

1.41

0.0451

-

miR-449a

20.31

32.65

1.61

0.0451

-

miR-3139

8.59

2.27

0.26

0.0031

-

miR-4449

10.95

2.75

0.25

0.0163

-

miR-4521

335.51

168.04

0.50

0.0194

-

miR-138-2-3p

94.11

74.60

0.79

0.0194

-

  1. MiRNAs upregulated in HD brains are indicated by a fold-change > 1, downregulated miRNAs by a fold-change < 1. NEV corresponds to the normalized expression value and FDR is the corrected p-value. Other studies indicates if any study different from this has likewise reported the miRNA deregulation in HD.