Overall global cognition
|
0.4 [0.2 – 0.7]
|
0.2 [0.1 – 0.3], p < 0.001
|
-1.2 [-1.4 – -0.9]
|
0.01 [-0.1 – 0.1], p = 0.8
|
-0.2 [-0.4 – -0.1], p = 0.006
|
Executive function
|
0.8 [0.4 – 1.2]
|
0.1[-0.04 – 0.1], p = 0.1
|
-1.4 [-1.7 – -1.0]
|
-0.2 [-0.4 - -0.02], p = 0.03
|
-0.3 [-0.6 – -0.1], p = 0.01
|
Working memory & attention
|
0.2 [-0.1 – 0.5]
|
0.2 [0.05 – 0.3], p = 0.01
|
-1.0 [-1.2 – -0.7]
|
0.08 [-0.1 – 0.2], p = 0.3
|
-0.1 [-0.3 – 0.1], p = 0.3
|
Learning & memory
|
0.5 [0.1 – 0.9]
|
0.6 [0.3 – 0.9], p < 0.001
|
-1.0 [-1.4 – -0.6]
|
-0.04 [-0.3 – 0.2], p = 0.8
|
-0.6 [-1.0 – -0.3], p < 0.001
|
Processing speed
|
0.7 [0.3 – 1.1]
|
0.1 [0.01 – 0.03], p = 0.04
|
-1.4 [-1.8 – -1.0]
|
-0.01 [-0.1 – 0.1] p = 0.8
|
-0.2 [-0.3 – 0.02], p = 0.09
|
Language
|
0.1 [-0.2 – 0.4]
|
0.3 [0.1 – 0.6], p = 0.008
|
-0.9 [-1.2 – -0.6]
|
0.3 [0.1 – 0.6], p = 0.01
|
-0.02 [-0.4 – 0.3], p = 0.9
|
Visuospatial
|
0.3 [0.0 – 0.6]
|
-0.02 [-0.2 – 0.2], p = 0.8
|
-1.4 [-1.7 – -1.1]
|
-0.07 [-0.2 – 0.3], p = 0.5
|
-0.04 [-0.3 – 0.2], p = 0.8
|
UHDRS cognitive score
|
0.6 [0.2 – 1.0]
|
0.06 [-0.1 – 0.2], p = 0.5
|
-1.5 [-1.9 – -1.1]
|
-0.2 [-0.3 - -0.001], p = 0.048
|
-0.2 [-0.4 – 0.01], p = 0.06
|
Measures
|
Points
|
Control group
|
HD group
|
HD vs. Controls
|
|
BaselineMean [95% CI]
|
Change after 12 monthsMean [95% CI]
|
BaselineMean [95% CI]
|
Change after 12 monthsMean [95% CI]
|
Relative change after 12 monthsMean [95% CI]
|
MMSE
| | | | | |
with WORLD item
|
29 [28 – 30]
|
0.4 [-0.3 – 1.1], p = 0.3
|
26 [25 – 28]
|
-0.8 [-1.5 – 0.08], p = 0.03
|
-1.2 [-2.2 – -0.2], p = 0.02
|
with Sevens item
|
29 [28 – 30]
|
0.5 [-0.4 – 1.4], p = 0.3
|
25 [24 – 26]
|
-0.5 [-1.3 – 0.4], p = 0.3
|
-1.0 [-2.2 – 0.3], p = 0.1
|
MoCA
|
28 [26 – 30]
|
0.4 [-0.6 – 1.4], p = 0.5
|
21 [20 – 23]
|
-0.5 [-1.5 – 0.5], p = 0.3
|
-0.9 [-2.3 – 0.5], p = 0.2
|
UHDRS motor score*
|
-
|
-
|
42 [33 – 51]
|
7.4 [3.4 – 11.3], p < 0.001
|
-
|
UHDRS behavioural score*
|
-
|
-
|
23 [17 – 30]
|
0.7 [-6.4 – 7.8], p = 0.8
|
-
|