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Table 2 Scores # at baseline, within-group changes and group over time interactions of control and HD groups

From: Comparison of cognitive and UHDRS measures in monitoring disease progression in Huntington’s disease: a 12-month longitudinal study

Measures z-scores
Control group HD group HD vs. Controls
  BaselineMean [95% CI] Change after 12 monthsMean [95% CI] BaselineMean [95% CI] Change after 12 monthsMean [95% CI] Relative change after 12 monthsMean [95% CI]
Overall global cognition 0.4 [0.2 – 0.7] 0.2 [0.1 – 0.3], p < 0.001 -1.2 [-1.4 – -0.9] 0.01 [-0.1 – 0.1], p = 0.8 -0.2 [-0.4 – -0.1], p = 0.006
Executive function 0.8 [0.4 – 1.2] 0.1[-0.04 – 0.1], p = 0.1 -1.4 [-1.7 – -1.0] -0.2 [-0.4 - -0.02], p = 0.03 -0.3 [-0.6 – -0.1], p = 0.01
Working memory & attention 0.2 [-0.1 – 0.5] 0.2 [0.05 – 0.3], p = 0.01 -1.0 [-1.2 – -0.7] 0.08 [-0.1 – 0.2], p = 0.3 -0.1 [-0.3 – 0.1], p = 0.3
Learning & memory 0.5 [0.1 – 0.9] 0.6 [0.3 – 0.9], p < 0.001 -1.0 [-1.4 – -0.6] -0.04 [-0.3 – 0.2], p = 0.8 -0.6 [-1.0 – -0.3], p < 0.001
Processing speed 0.7 [0.3 – 1.1] 0.1 [0.01 – 0.03], p = 0.04 -1.4 [-1.8 – -1.0] -0.01 [-0.1 – 0.1] p = 0.8 -0.2 [-0.3 – 0.02], p = 0.09
Language 0.1 [-0.2 – 0.4] 0.3 [0.1 – 0.6], p = 0.008 -0.9 [-1.2 – -0.6] 0.3 [0.1 – 0.6], p = 0.01 -0.02 [-0.4 – 0.3], p = 0.9
Visuospatial 0.3 [0.0 – 0.6] -0.02 [-0.2 – 0.2], p = 0.8 -1.4 [-1.7 – -1.1] -0.07 [-0.2 – 0.3], p = 0.5 -0.04 [-0.3 – 0.2], p = 0.8
UHDRS cognitive score 0.6 [0.2 – 1.0] 0.06 [-0.1 – 0.2], p = 0.5 -1.5 [-1.9 – -1.1] -0.2 [-0.3 - -0.001], p = 0.048 -0.2 [-0.4 – 0.01], p = 0.06
Measures Points
Control group HD group HD vs. Controls
  BaselineMean [95% CI] Change after 12 monthsMean [95% CI] BaselineMean [95% CI] Change after 12 monthsMean [95% CI] Relative change after 12 monthsMean [95% CI]
MMSE      
with WORLD item 29 [28 – 30] 0.4 [-0.3 – 1.1], p = 0.3 26 [25 – 28] -0.8 [-1.5 – 0.08], p = 0.03 -1.2 [-2.2 – -0.2], p = 0.02
with Sevens item 29 [28 – 30] 0.5 [-0.4 – 1.4], p = 0.3 25 [24 – 26] -0.5 [-1.3 – 0.4], p = 0.3 -1.0 [-2.2 – 0.3], p = 0.1
MoCA 28 [26 – 30] 0.4 [-0.6 – 1.4], p = 0.5 21 [20 – 23] -0.5 [-1.5 – 0.5], p = 0.3 -0.9 [-2.3 – 0.5], p = 0.2
UHDRS motor score* - - 42 [33 – 51] 7.4 [3.4 – 11.3], p < 0.001 -
UHDRS behavioural score* - - 23 [17 – 30] 0.7 [-6.4 – 7.8], p = 0.8 -
  1. *UHDRS motor and behavioural components were assessed in the HD group only.
  2. #Baseline and 12-month SD and ranges for all variables are detailed in Additional file 2: Table S1 and score changes after 12 months in individual component tests are shown in Additional file 1: Figure S1.
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Translational Neurodegeneration

ISSN: 2047-9158

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