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Table 2 Scores # at baseline, within-group changes and group over time interactions of control and HD groups

From: Comparison of cognitive and UHDRS measures in monitoring disease progression in Huntington’s disease: a 12-month longitudinal study

Measures

z-scores

Control group

HD group

HD vs. Controls

 

BaselineMean [95% CI]

Change after 12 monthsMean [95% CI]

BaselineMean [95% CI]

Change after 12 monthsMean [95% CI]

Relative change after 12 monthsMean [95% CI]

Overall global cognition

0.4 [0.2 – 0.7]

0.2 [0.1 – 0.3], p < 0.001

-1.2 [-1.4 – -0.9]

0.01 [-0.1 – 0.1], p = 0.8

-0.2 [-0.4 – -0.1], p = 0.006

Executive function

0.8 [0.4 – 1.2]

0.1[-0.04 – 0.1], p = 0.1

-1.4 [-1.7 – -1.0]

-0.2 [-0.4 - -0.02], p = 0.03

-0.3 [-0.6 – -0.1], p = 0.01

Working memory & attention

0.2 [-0.1 – 0.5]

0.2 [0.05 – 0.3], p = 0.01

-1.0 [-1.2 – -0.7]

0.08 [-0.1 – 0.2], p = 0.3

-0.1 [-0.3 – 0.1], p = 0.3

Learning & memory

0.5 [0.1 – 0.9]

0.6 [0.3 – 0.9], p < 0.001

-1.0 [-1.4 – -0.6]

-0.04 [-0.3 – 0.2], p = 0.8

-0.6 [-1.0 – -0.3], p < 0.001

Processing speed

0.7 [0.3 – 1.1]

0.1 [0.01 – 0.03], p = 0.04

-1.4 [-1.8 – -1.0]

-0.01 [-0.1 – 0.1] p = 0.8

-0.2 [-0.3 – 0.02], p = 0.09

Language

0.1 [-0.2 – 0.4]

0.3 [0.1 – 0.6], p = 0.008

-0.9 [-1.2 – -0.6]

0.3 [0.1 – 0.6], p = 0.01

-0.02 [-0.4 – 0.3], p = 0.9

Visuospatial

0.3 [0.0 – 0.6]

-0.02 [-0.2 – 0.2], p = 0.8

-1.4 [-1.7 – -1.1]

-0.07 [-0.2 – 0.3], p = 0.5

-0.04 [-0.3 – 0.2], p = 0.8

UHDRS cognitive score

0.6 [0.2 – 1.0]

0.06 [-0.1 – 0.2], p = 0.5

-1.5 [-1.9 – -1.1]

-0.2 [-0.3 - -0.001], p = 0.048

-0.2 [-0.4 – 0.01], p = 0.06

Measures

Points

Control group

HD group

HD vs. Controls

 

BaselineMean [95% CI]

Change after 12 monthsMean [95% CI]

BaselineMean [95% CI]

Change after 12 monthsMean [95% CI]

Relative change after 12 monthsMean [95% CI]

MMSE

     

with WORLD item

29 [28 – 30]

0.4 [-0.3 – 1.1], p = 0.3

26 [25 – 28]

-0.8 [-1.5 – 0.08], p = 0.03

-1.2 [-2.2 – -0.2], p = 0.02

with Sevens item

29 [28 – 30]

0.5 [-0.4 – 1.4], p = 0.3

25 [24 – 26]

-0.5 [-1.3 – 0.4], p = 0.3

-1.0 [-2.2 – 0.3], p = 0.1

MoCA

28 [26 – 30]

0.4 [-0.6 – 1.4], p = 0.5

21 [20 – 23]

-0.5 [-1.5 – 0.5], p = 0.3

-0.9 [-2.3 – 0.5], p = 0.2

UHDRS motor score*

-

-

42 [33 – 51]

7.4 [3.4 – 11.3], p < 0.001

-

UHDRS behavioural score*

-

-

23 [17 – 30]

0.7 [-6.4 – 7.8], p = 0.8

-

  1. *UHDRS motor and behavioural components were assessed in the HD group only.
  2. #Baseline and 12-month SD and ranges for all variables are detailed in Additional file 2: Table S1 and score changes after 12 months in individual component tests are shown in Additional file 1: Figure S1.