Measures | z-scores | ||||
---|---|---|---|---|---|
Control group | HD group | HD vs. Controls | |||
BaselineMean [95% CI] | Change after 12 monthsMean [95% CI] | BaselineMean [95% CI] | Change after 12 monthsMean [95% CI] | Relative change after 12 monthsMean [95% CI] | |
Overall global cognition | 0.4 [0.2 – 0.7] | 0.2 [0.1 – 0.3], p < 0.001 | -1.2 [-1.4 – -0.9] | 0.01 [-0.1 – 0.1], p = 0.8 | -0.2 [-0.4 – -0.1], p = 0.006 |
Executive function | 0.8 [0.4 – 1.2] | 0.1[-0.04 – 0.1], p = 0.1 | -1.4 [-1.7 – -1.0] | -0.2 [-0.4 - -0.02], p = 0.03 | -0.3 [-0.6 – -0.1], p = 0.01 |
Working memory & attention | 0.2 [-0.1 – 0.5] | 0.2 [0.05 – 0.3], p = 0.01 | -1.0 [-1.2 – -0.7] | 0.08 [-0.1 – 0.2], p = 0.3 | -0.1 [-0.3 – 0.1], p = 0.3 |
Learning & memory | 0.5 [0.1 – 0.9] | 0.6 [0.3 – 0.9], p < 0.001 | -1.0 [-1.4 – -0.6] | -0.04 [-0.3 – 0.2], p = 0.8 | -0.6 [-1.0 – -0.3], p < 0.001 |
Processing speed | 0.7 [0.3 – 1.1] | 0.1 [0.01 – 0.03], p = 0.04 | -1.4 [-1.8 – -1.0] | -0.01 [-0.1 – 0.1] p = 0.8 | -0.2 [-0.3 – 0.02], p = 0.09 |
Language | 0.1 [-0.2 – 0.4] | 0.3 [0.1 – 0.6], p = 0.008 | -0.9 [-1.2 – -0.6] | 0.3 [0.1 – 0.6], p = 0.01 | -0.02 [-0.4 – 0.3], p = 0.9 |
Visuospatial | 0.3 [0.0 – 0.6] | -0.02 [-0.2 – 0.2], p = 0.8 | -1.4 [-1.7 – -1.1] | -0.07 [-0.2 – 0.3], p = 0.5 | -0.04 [-0.3 – 0.2], p = 0.8 |
UHDRS cognitive score | 0.6 [0.2 – 1.0] | 0.06 [-0.1 – 0.2], p = 0.5 | -1.5 [-1.9 – -1.1] | -0.2 [-0.3 - -0.001], p = 0.048 | -0.2 [-0.4 – 0.01], p = 0.06 |
Measures | Points | ||||
Control group | HD group | HD vs. Controls | |||
BaselineMean [95% CI] | Change after 12 monthsMean [95% CI] | BaselineMean [95% CI] | Change after 12 monthsMean [95% CI] | Relative change after 12 monthsMean [95% CI] | |
MMSE | |||||
with WORLD item | 29 [28 – 30] | 0.4 [-0.3 – 1.1], p = 0.3 | 26 [25 – 28] | -0.8 [-1.5 – 0.08], p = 0.03 | -1.2 [-2.2 – -0.2], p = 0.02 |
with Sevens item | 29 [28 – 30] | 0.5 [-0.4 – 1.4], p = 0.3 | 25 [24 – 26] | -0.5 [-1.3 – 0.4], p = 0.3 | -1.0 [-2.2 – 0.3], p = 0.1 |
MoCA | 28 [26 – 30] | 0.4 [-0.6 – 1.4], p = 0.5 | 21 [20 – 23] | -0.5 [-1.5 – 0.5], p = 0.3 | -0.9 [-2.3 – 0.5], p = 0.2 |
UHDRS motor score* | - | - | 42 [33 – 51] | 7.4 [3.4 – 11.3], p < 0.001 | - |
UHDRS behavioural score* | - | - | 23 [17 – 30] | 0.7 [-6.4 – 7.8], p = 0.8 | - |