Randomized controlled trials in frontotemporal dementia: cognitive and behavioral outcomes

Table 1 Summary of published endpoints in randomized controlled trials in frontotemporal dementia

Study	Sample size	Global endpoints	Cognitive endpoints	Behavioral endpoints
Moretti, R. et al. [20]	16	---	MMSE, Ten Point Clock Test, Proverb Interpretation Tasks, Stroop Test	NPI, CIRS, CSDD, BEHAVE-AD
Deakin, J.B. et al. [21]	10	---	CANTAB*, Verbal fluency, Digit Span	NPI, CBI
Lebert, F. [22]	26	CGI-I	MMSE	NPI
Rahman, S. [23]	8	---	NART, MMSE, CANTAB**, Cambridge Gamble Task	---
Huey, E.D. [24]	8	---	RBANS	NPI
Kertesz, A. [25]	36	CGI-S, CGI-I	WAB, MMSE, DRS	FBI, NPI, ADLS
Vercelletto, M. [19]	49	CIBIC+	MMSE, DRS	NPI, FBI, DAD, ZBI
Boxer, A.L. [7]	81	CGI-C	CVLT, fluency, BNT, Trail Making test, Digit Backwards, Digit symbol	NPI
Jesso, S. [26]	20	---	Emotion recognition, emotion processing, Theory of Mind task	NPI, FBI

ADLS, alzheimer’s disease cooperative study—activities of daily living scale; BEHAV-AD, behavioral pathology in alzheimer’s disease rating scale; BNT, Boston naming test; CBI, Cambridge behavioral inventory; CGI-C, clinical global impression of change; CGI-I, clinical global impression of improvement; CGI-S, clinical global impression of severity; CIBIC+, clinician’s interview-based impression of change plus caregiver input; CIRS, clinical insight rating scale; CSDD, cornell scale for depression in dementia; CVLT, California verbal learning test; DAD, disability assessment for dementia; DRS, dementia rating scale, FBI, frontal behavioral inventory; MMSE, mini mental status exam; NART, National test of adult reading; NPI, neuropsychiatric inventory; RBANS, repeatable battery for the assessment of neuropsychological status; WAB, Western Aphasia battery; ZBI, Zarit burden inventory.
*(immediate and delayed pattern recognition, spatial recognition, spatial span, spatial working memory, visual discrimination learning/attentional set shifting, decision-making “gamble,” and paired associates learning).
**(pattern recognition memory, spatial recognition memory, spatial span, spatial working memory, and intradimensional (ID)/extradimensional (ED) attentional-set shifting, and Tower of London test of spatial planning).

ISSN: 2047-9158