From: Considerations on the role of environmental toxins in idiopathic Parkinson’s disease pathophysiology
Locus | Chromosome’Location | Gene | Inheritance | Typical pheno-type | Reference |
---|---|---|---|---|---|
PARK1 & PARK4 | 4q21-q23 | α-synuclein | AD | Earlier onset, features of DLB’common | |
PARK2 | 6q25.2-q27 | parkin | usually AR | Earlier onset with slow progression | [74] |
PARK3 | 2p13 | unknown | AD, IP | Classic PD,’sometimes de-mentia | [4] |
PARK5 | 4p14 | UCH-L1 | AD | Classic PD | [75] |
PARK6 | 1p35-p36 | PINK1 | AR | Earlier onset with’slow progression | [76] |
PARK7 | 1p36 | DJ-1 | AR | Earlier onset with’slow progression | [67] |
PARK8 | 12p11.2-q13.1 | LRRK2 | AD | Classic PD | [77] |
PARK10 | 1p32 | unknown | Unclear | Classic PD | [78] |
PARK11 | 2q36-q37 | unknown | Unclear | Classic PD | [79] |
NA | 5q23.1-q23.3 | Synphilin1 | Unclear | Classic PD | [80] |
NA | 2q22-q23 | NR4A2 | Unclear | Classic PD | [81] |