Figure 1
From: Can we clinically diagnose dementia with Lewy bodies yet?
Lewy-related pathologies (LRP) and Aβ deposition in DLB. (A-C) Histofluorecence identification of α-synuclein-positive (A, green) Lewy bodies using thioflavin S (B, blue) for filament localization (C, merge) showing difficulty with immunostaining the mature core filaments of midbrain Lewy bodies. (D) Eosinophilic Lewy body in a pigmented midbrain dopaminergic neuron, (E) mature α-synuclein-positive Lewy body in the neocortex identified using peroxidase immunohistochemistry, (F) immature α-synuclein-positive Lewy body and related star-shaped α-synuclein-positive astrocytes in the neocortex identified using peroxidase immunohistochemistry. (G) α-synuclein-positive Lewy neurites in the hippocampal CA2 region identified using peroxidase immunohistochemistry, and (H) Aβ-positive cortical plaques identified using peroxidase immunohistochemistry. The scale in F and G is equal to that in E.