Table 3 Randomized controlled trials comparing STN and GPi DBS
Author, year | Number of patients | Follow up | Side | Similar results | Differences in results |
|---|---|---|---|---|---|
Anderson et al., 2005 [115] | 20 | 12 months | Bilateral | -Motor symptoms | -Greater decrease in dopaminergic drug dosage with STN. |
-Cognitive and behavioral complications exclusively with STN. | |||||
Okun et al., 2009 [116] | 45 | 7 months | Unilateral | -Motor symptoms. | -Worse verbal fluency with STN. |
-Side effects including mood and cognition. | -Greater improvement in QOL with GPi [117]. | ||||
-Higher risk to require controlateral DBS implant in STN group [112]. | |||||
Follett et al., 2010 [57] | 299 | 24 months | Bilateral | -Motor symptoms. | -Greater decrease in dopaminergic drug dosage with STN. |
-Side effects profile. | -Worse decline in visuomotor processing with STN | ||||
-Depression improved with GPi but worsened with STN. | |||||
Weaver et al., 2012 [118] | 159 | 36 months | Bilateral | -Motor symptoms. | -Greater decrease in dopaminergic drug with STN. |
-Side effects profile. | -Worse cognitive performance with STN | ||||
Odekerken et al., 2013 [119] | 128 | 12 months | Bilateral | -Quality of life. | -Greater decrease in dopaminergic drug dosage with STN. |
-Cognitive, psychiatric and behavioral side effects | -Greater improvement in the OFF phase motor score with STN | ||||
- Greater improvement in disability with STN |