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Table 3 Randomized controlled trials comparing STN and GPi DBS

From: Deep brain stimulation in Parkinson’s disease

Author, year Number of patients Follow up Side Similar results Differences in results
Anderson et al., 2005 [115] 20 12 months Bilateral -Motor symptoms -Greater decrease in dopaminergic drug dosage with STN.
  -Cognitive and behavioral complications exclusively with STN.
Okun et al., 2009 [116] 45 7 months Unilateral -Motor symptoms. -Worse verbal fluency with STN.
-Side effects including mood and cognition. -Greater improvement in QOL with GPi [117].
  -Higher risk to require controlateral DBS implant in STN group [112].
Follett et al., 2010 [57] 299 24 months Bilateral -Motor symptoms. -Greater decrease in dopaminergic drug dosage with STN.
-Side effects profile. -Worse decline in visuomotor processing with STN
-Depression improved with GPi but worsened with STN.
Weaver et al., 2012 [118] 159 36 months Bilateral -Motor symptoms. -Greater decrease in dopaminergic drug with STN.
-Side effects profile. -Worse cognitive performance with STN
Odekerken et al., 2013 [119] 128 12 months Bilateral -Quality of life. -Greater decrease in dopaminergic drug dosage with STN.
-Cognitive, psychiatric and behavioral side effects -Greater improvement in the OFF phase motor score with STN
  - Greater improvement in disability with STN
  1. Legend: STN: subthalamic nucleus; GPi: Globus pallidum pars interna; DBS: deep brain stimulation; QOL: quality of life.