Figure 3

γ-secretase complex and the formation of the catalytic pore of PS1. PS1 transmembrane domains (TMDs) are shown as columns with numbers. Without the assistance of other subunits, PS1 forms a relatively open pore structure within the membrane. Upon the binding of subunits, the PALP motif moves to the proximity of the catalytic center, and the catalytic structure is activated by the structural changes in TMDs of PS1.