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Figure 1 | Translational Neurodegeneration

Figure 1

From: Biological function of Presenilin and its role in AD pathogenesis

Figure 1

APP processing pathways. Under the physiological conditions, the majority of APP undergoes the non-amyloidogenic pathway. The α-secretase processes APP within the Aβ domain to generate C83 and this cleavage abolishes Aβ generation. In the amyloidogenic pathway, β-secretase processes APP at Asp1 site to generate C99 fragment, which is the substrate for γ-secretase for Aβ generation.

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