Figure 1From: Biological function of Presenilin and its role in AD pathogenesisAPP processing pathways. Under the physiological conditions, the majority of APP undergoes the non-amyloidogenic pathway. The α-secretase processes APP within the Aβ domain to generate C83 and this cleavage abolishes Aβ generation. In the amyloidogenic pathway, β-secretase processes APP at Asp1 site to generate C99 fragment, which is the substrate for γ-secretase for Aβ generation.Back to article page