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Figure 1 | Translational Neurodegeneration

Figure 1

From: Intranuclear inclusions in a fragile X mosaic male

Figure 1

Southern blot analysis of genomic DNA isolate from two controls: C1 (negative control, normal female with two normal alleles and the corresponding 5.2 Kb and 2.8 Kb bands (methylated and unmethylated alleles respectively) and C2 (positive control, full mutation male with a methylated band of ~ 800 CGG repeats). Both a premutation allele and a full mutation alleles are present in blood (lane 1), cerebellum (lane 2), and frontal cortex (lane 3) of the proband. DNA marker (M) 1 kb ladder is shown in Lane 1.

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