Figure 5
From: Erythropoietin prevents PC12 cells from beta-amyloid-induced apoptosis via PI3K⁄Akt pathway
Effect of Epo on 20 μM Abeta (25-35) -induced cell apoptosis. Western blotting analysis indicated that the Abeta(25-35) treatment of PC12 cells could decrease the expression of Bcl-2 (P < 0.05) (A), and increase the expression of Bax (P < 0.05) (A), Cleaved casapase-3 (P < 0.05) (B), and Cleaved PARP (P < 0.05) (C). Three different Epo concentrations could prevent all the changes induced by Abeta(25-35) (P < 0.05) (A-C). Three independent experiments were performed in duplicate (*: P < 0.05 vs. the controls and #: P < 0.05 vs. 20 μM Abeta(25-35))