Figure 3From: Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson’s disease through suppressing mitochondria dysfunctionEffects of curcumin on the phosphorylation of JNKs. Effects of curcumin on the phosphorylation of JNKs in SNc. Bands corresponding to JNK3 and p-JNK3 were scanned and the intensities were represented as folds vs. saline animals. Phosphorylation of JNK3 was examined by immunoprecipitation (IP) with anti-p-JNKs antibody followed by immunoblotting (IB) with antibody against JNK3. P-JNK1/2 was examined by IB with antibody against p-JNK1/2. The protein levels of JNK1/2 and J NK3 were examined by immunoblotting with anti-JNK1/2 and anti-JNK3 antibodies. Data are expressed as the mean ± SD and as folds vs. respective saline groups. aP < 0.05 vs. saline; bP <0.05 vs. MPTP groups (n = 6 mice).Back to article page