Table 2 Asymptomatic persons with positive biomarkers of AD [modified from 10]
Stage | Biomarkers or evidence | ||
|---|---|---|---|
Aß (amyloid PET or CSF) | Neuronal injury (tau in CSF, FDG-PET, structural MRI) | Evidence of cognitive decline | |
asymptomatic cerebral amyloidosis (ACA) | positive | negative | negative |
ACA + neuronal injury (NI) | positive | positive | negative |
ACA + NI + subtle cognitive decline | positive | positive | positive |