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Table 2 Current available, approved dopamine agonists

From: Drug therapy in patients with Parkinson’s disease

compound

dose range

administration

half life

bromocriptine

10 - 50

oral, t.i.d.

3 – 6

lisurid

0.2 - 3

oral, 12 i.d.

2

pergolid

0.5 - 6

oral, t.i.d.

6-8

dihydro-α-ergocryptine

20 - 120

oral, t.i.d.

16

cabergoline

0.5 - 4

oral, o.i.d.

63

rotigotine

2 - 16

patch, t.i.d.

24

Pramipexol [retarded release]

0.25 - 4.5

oral, t.i.d.[o.i.d. – b.i.d.]

8 [24]

Ropinirol [retarded release]

4 - 24

oral, o.i.d. [o.i.d. – b.i.d.]

6 [24]

Piribedil retarded release

50 - 250

oral, t.i.d.

21

  1. Dose range is given in mg, only approved dopamine agonist with oral or transdermal administration are listed, plasma half life is given in hours, 10 mg bromocriptine correspond to approximately 400 mg LD/DDI.