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  1. Review

    Genotype-phenotype correlations of amyotrophic lateral sclerosis

    Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive neuronal loss and degeneration of upper motor neuron (UMN) and lower motor neuron (LMN). The clinical...

    Hong-Fu Li and Zhi-Ying Wu

    Translational Neurodegeneration 2016 5:3

    Published on: 3 February 2016

  2. Short report

    Pilot study of atomoxetine in patients with Parkinson’s disease and dopa-unresponsive Freezing of Gait

    Freezing of gait (FoG) is a common and debilitating condition in Parkinson’s disease (PD) associated with executive dysfunction. A subtype of FoG does not respond to dopaminergic therapy and may be related to ...

    Gonzalo J. Revuelta, Aaron Embry, Jordan J. Elm, Chris Gregory, Amy Delambo, Steve Kautz and Vanessa K. Hinson

    Translational Neurodegeneration 2015 4:24

    Published on: 10 December 2015

  3. Research

    No apparent transmission of transgenic α–synuclein into nigrostriatal dopaminergic neurons in multiple mouse models

    α–synuclein (α–syn) is the main component of intracytoplasmic inclusions deposited in the brains of patients with Parkinson’s disease (PD) and certain other neurodegenerative disorders. Recent studies have exp...

    Namratha Sastry, Wang Zheng, Guoxiang Liu, Helen Wang, Xi Chen, Michael Cai, Parth Contractor, Carmelo Sgobio, Lixin Sun, Chengsong Xie and Huaibin Cai

    Translational Neurodegeneration 2015 4:23

    Published on: 3 December 2015

  4. Review

    Development of stem cell-based therapy for Parkinson’s disease

    Parkinson’s disease (PD) is one of the most common neurodegenerative disorders of aging, characterized by the degeneration of dopamine neurons (DA neurons) in the substantial nigra, leading to the advent of bo...

    Fabin Han, Deborah Baremberg, Junyu Gao, Jing Duan, Xianjie Lu, Nan Zhang and Qingfa Chen

    Translational Neurodegeneration 2015 4:16

    Published on: 3 September 2015

  5. Research

    Clinical management and associated costs for moderate and severe Alzheimer’s disease in urban China: a Delphi panel study

    Healthcare resource utilisation for Alzheimer’s disease (AD) in China is not well understood. This Delphi panel study aimed to describe the clinical management pathways for moderate and severe AD patients in u...

    Xin Yu, Shengdi Chen, Xiaochun Chen, Jianjun Jia, Chunhou Li, Cong Liu, Mondher Toumi and Dominique Milea

    Translational Neurodegeneration 2015 4:15

    Published on: 20 August 2015

  6. Review

    Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis

    Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease characterized by progressive loss of motor neurons in the brainstem and spinal cord. Currently, there is no cure or effective treatme...

    Zhen Jiang, Wenzhang Wang, George Perry, Xiongwei Zhu and Xinglong Wang

    Translational Neurodegeneration 2015 4:14

    Published on: 29 July 2015

  7. Review

    Update on deep brain stimulation in Parkinson’s disease

    Deep brain stimulation (DBS) is considered a safe and well tolerated surgical procedure to alleviate Parkinson’s disease (PD) and other movement disorders symptoms along with some psychiatric conditions. Over ...

    Daniel Martinez-Ramirez, Wei Hu, Alberto R. Bona, Michael S. Okun and Aparna Wagle Shukla

    Translational Neurodegeneration 2015 4:12

    Published on: 27 June 2015

  8. Research

    Posttranslational modifications of α-tubulin in alzheimer disease

    In Alzheimer disease (AD), hyperphosphorylation of tau proteins results in microtubule destabilization and cytoskeletal abnormalities. Our prior ultra-morphometric studies documented a clear reduction in micro...

    Fan Zhang, Bo Su, Chunyu Wang, Sandra L. Siedlak, Siddhartha Mondragon-Rodriguez, Hyoung-gon Lee, Xinglong Wang, George Perry and Xiongwei Zhu

    Translational Neurodegeneration 2015 4:9

    Published on: 15 May 2015

  9. Review

    The promise of stem cells in the therapy of Alzheimer’s disease

    Alzheimer’s disease (AD), a common neurodegenerative disorder associated with gradually to dramatic neuronal death, synaptic loss and dementia, is considered to be one of the most obscure and intractable brain...

    Chunmei Yue and Naihe Jing

    Translational Neurodegeneration 2015 4:8

    Published on: 28 April 2015

  10. Review

    Direct reprogramming of induced neural progenitors: a new promising strategy for AD treatment

    Alzheimer’s disease (AD) is a prominent form of dementia, characterized by aggregation of the amyloid β-peptide (Aβ) plaques and neurofibrillary tangles, loss of synapses and neurons, and degeneration of cogni...

    Siqiang Lai, Min Zhang, Dongsheng Xu, Yiying Zhang, Lisha Qiu, Changhai Tian and Jialin Charlie Zheng

    Translational Neurodegeneration 2015 4:7

    Published on: 18 April 2015

  11. Review

    Mini review: linkage between α-Synuclein protein and cognition

    α-synuclein is a protein that plays important roles in cognitive function in the normal brain, although its exact role is not fully understood. However, current studies reveal that defects in α-synuclein funct...

    Huda Saleh, Ayeh Saleh, Hailan Yao, Jie Cui, Yong Shen and Rena Li

    Translational Neurodegeneration 2015 4:5

    Published on: 28 March 2015

  12. Research

    Voxel-based meta-analysis of grey matter changes in Alzheimer’s disease

    Voxel-based morphometry (VBM) using structural brain MRI has been widely used for the assessment of impairment in Alzheimer’s disease (AD), but previous studies in VBM studies on AD remain inconsistent.

    Wen-Ying Wang, Jin-Tai Yu, Yong Liu, Rui-Hua Yin, Hui-Fu Wang, Jun Wang, Lin Tan, Joaquim Radua and Lan Tan

    Translational Neurodegeneration 2015 4:6

    Published on: 27 March 2015

  13. Review

    How to optimize the treatment of early stage Parkinson’s disease

    The approach to early Parkinson’s disease denotes the communication of the diagnosis and important decisions, such as when and how to start treatment. Evidence based medicine and guidelines indicate which drug...

    Fabrizio Stocchi, Laura Vacca and Fabiana G Radicati

    Translational Neurodegeneration 2015 4:4

    Published on: 25 February 2015

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