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  1. Research

    Methylation status of DJ-1 in leukocyte DNA of Parkinson’s disease patients

    DJ-1 has been thought as a candidate biomarker for Parkinson’s disease (PD). It was found reduced in PD brains, CSF and saliva, although there were conflicting results. How DJ-1 expression may be regulated is ...

    Yuyan Tan, Li Wu, Dunhui Li, Xiaoli Liu, Jianqing Ding and Shengdi Chen

    Translational Neurodegeneration 2016 5:5

    Published on: 31 March 2016

  2. Research

    miRNA expression profiles in cerebrospinal fluid and blood of patients with Alzheimer’s disease and other types of dementia – an exploratory study

    MicroRNAs (miRNAs) are small non-coding RNA molecules that function as posttranscriptional regulators of gene expression. Measurements of miRNAs in cerebrospinal fluid (CSF) and blood have just started gaining...

    Sofie Sølvsten Sørensen, Ann-Britt Nygaard and Thomas Christensen

    Translational Neurodegeneration 2016 5:6

    Published on: 15 March 2016

  3. Review

    Genotype-phenotype correlations of amyotrophic lateral sclerosis

    Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive neuronal loss and degeneration of upper motor neuron (UMN) and lower motor neuron (LMN). The clinical...

    Hong-Fu Li and Zhi-Ying Wu

    Translational Neurodegeneration 2016 5:3

    Published on: 3 February 2016

  4. Short report

    Pilot study of atomoxetine in patients with Parkinson’s disease and dopa-unresponsive Freezing of Gait

    Freezing of gait (FoG) is a common and debilitating condition in Parkinson’s disease (PD) associated with executive dysfunction. A subtype of FoG does not respond to dopaminergic therapy and may be related to ...

    Gonzalo J. Revuelta, Aaron Embry, Jordan J. Elm, Chris Gregory, Amy Delambo, Steve Kautz and Vanessa K. Hinson

    Translational Neurodegeneration 2015 4:24

    Published on: 10 December 2015

  5. Research

    No apparent transmission of transgenic α–synuclein into nigrostriatal dopaminergic neurons in multiple mouse models

    α–synuclein (α–syn) is the main component of intracytoplasmic inclusions deposited in the brains of patients with Parkinson’s disease (PD) and certain other neurodegenerative disorders. Recent studies have exp...

    Namratha Sastry, Wang Zheng, Guoxiang Liu, Helen Wang, Xi Chen, Michael Cai, Parth Contractor, Carmelo Sgobio, Lixin Sun, Chengsong Xie and Huaibin Cai

    Translational Neurodegeneration 2015 4:23

    Published on: 3 December 2015

  6. Review

    Development of stem cell-based therapy for Parkinson’s disease

    Parkinson’s disease (PD) is one of the most common neurodegenerative disorders of aging, characterized by the degeneration of dopamine neurons (DA neurons) in the substantial nigra, leading to the advent of bo...

    Fabin Han, Deborah Baremberg, Junyu Gao, Jing Duan, Xianjie Lu, Nan Zhang and Qingfa Chen

    Translational Neurodegeneration 2015 4:16

    Published on: 3 September 2015

  7. Research

    Clinical management and associated costs for moderate and severe Alzheimer’s disease in urban China: a Delphi panel study

    Healthcare resource utilisation for Alzheimer’s disease (AD) in China is not well understood. This Delphi panel study aimed to describe the clinical management pathways for moderate and severe AD patients in u...

    Xin Yu, Shengdi Chen, Xiaochun Chen, Jianjun Jia, Chunhou Li, Cong Liu, Mondher Toumi and Dominique Milea

    Translational Neurodegeneration 2015 4:15

    Published on: 20 August 2015

  8. Review

    Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis

    Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease characterized by progressive loss of motor neurons in the brainstem and spinal cord. Currently, there is no cure or effective treatme...

    Zhen Jiang, Wenzhang Wang, George Perry, Xiongwei Zhu and Xinglong Wang

    Translational Neurodegeneration 2015 4:14

    Published on: 29 July 2015

  9. Review

    Update on deep brain stimulation in Parkinson’s disease

    Deep brain stimulation (DBS) is considered a safe and well tolerated surgical procedure to alleviate Parkinson’s disease (PD) and other movement disorders symptoms along with some psychiatric conditions. Over ...

    Daniel Martinez-Ramirez, Wei Hu, Alberto R. Bona, Michael S. Okun and Aparna Wagle Shukla

    Translational Neurodegeneration 2015 4:12

    Published on: 27 June 2015

  10. Research

    Posttranslational modifications of α-tubulin in alzheimer disease

    In Alzheimer disease (AD), hyperphosphorylation of tau proteins results in microtubule destabilization and cytoskeletal abnormalities. Our prior ultra-morphometric studies documented a clear reduction in micro...

    Fan Zhang, Bo Su, Chunyu Wang, Sandra L. Siedlak, Siddhartha Mondragon-Rodriguez, Hyoung-gon Lee, Xinglong Wang, George Perry and Xiongwei Zhu

    Translational Neurodegeneration 2015 4:9

    Published on: 15 May 2015

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