Fig. 4
From: Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration
Mechanisms of co-pathology formation between tau and α-syn. We propose three possible models of tau and α-syn co-pathology formation in neurons. (1) Tau and α-syn monomers directly bind to each other and form co-aggregates (left), (2) tau or α-syn aggregates serve as the template and initiate elongation with monomers of the other protein, a process termed cross-seeding (middle); and (3) tau and α-syn aggregate independently from each other in the same neurons