Fig. 3
From: Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration
Processes of tau and α-syn aggregation. Under pathological conditions, α-syn accumulates and forms the β-sheet structure in the cytoplasm, which then becomes an amyloid fibrillary structure, the main component of LBs. On the other hand, tau monomers become hyperphosphorylated and form numeric molecules, which then aggregate into protofilaments and form PHFs, eventually becoming NFTs