Fig. 2
From: Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration
Structure, mutations and PTMs of α-syn protein. α-Syn has three domains: the amphipathic N-terminus, the non-amyloid-β component (NAC) which is prone to aggregate, and the acidic C-terminus. Common point mutations of α-syn are A30P, E46K, H50Q, G51D, A53T and A53E. The PTMs of α-syn mainly include phosphorylation, nitration, acetylation, ubiquitination and SUMOylation [43, 162]