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Fig. 1 | Translational Neurodegeneration

Fig. 1

From: Dietary fasting and time-restricted eating in Huntington’s disease: therapeutic potential and underlying mechanisms

Fig. 1

Model of mechanisms underlying the therapeutic potential of time-restricted eating in Huntington’s disease (HD). Scheduled daily eating and fasting, known as time-restricted eating (TRE), in HD and non-HD human and animal studies reveals that the practice increases autophagic activity which is thought to decrease aggregation of the mutant huntingtin protein (mHTT), stimulates production of brain-derived neurotrophic factor (BDNF), improves metabolic functions, promotes oxidative stress resistance, decreases reactive oxygen species (ROS), and improves measures of circadian rhythm function. Created with BioRender.com

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Translational Neurodegeneration

ISSN: 2047-9158

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