Table 3 Clinicopathological features of each argyrophilic grain disease (AGD) pathological stage
|  | Negative cases (n = 1107) | Negative cases aged over 70 years (n = 480) | Stage I (n = 55) | Stage II (n = 126) | Stage III (n = 161) |
|---|---|---|---|---|---|
Age, mean ± SD, years | 67.0 ± 14.1 | 80.3 ± 6.3 | 76.2 ± 10.0**** | 79.9 ± 8.1 | 80.8 ± 9.0 |
Sex (male/female) | 704/403 | 262/218 | 28/27 | 60/66 | 89/72 |
BMI | 21.3 ± 4.5 | 20.2 ± 3.9 | 20.7 ± 3.4 | 19.6 ± 3.8 | 20.2 ± 3.5 |
Cause of death | |||||
 Suicide, n (%) | 286 (25.8) | 83 (17.3) | 19 (34.6)## | 37 (29.4)## | 53 (32.9)#### |
 Homicide, n (%) | 21 (1.9) | 8 (1.7) | 1 (1.8) | 0 (0.0) | 1 (0.6) |
 Accidental death, n (%) | 494 (44.6) | 280 (58.3) | 25 (45.5) | 65 (51.6) | 85 (52.8) |
 Natural causes, n (%) | 297 (26.8) | 106 (22.1) | 10 (18.2) | 22 (17.5) | 20 (12.4)## |
Past medical history | |||||
 Dementia, n (%) | 78 (7.1) | 70 (14.6) | 13 (23.6) | 32 (25.4)## | 35 (21.7)# |
 Medical history of psychiatric disorder, n (%) | 161 (14.5) | 37 (7.7) | 8 (14.6) | 17 (13.5)# | 26 (16.2)## |
Pathological findings | |||||
 Brain weight, mean ± SD, g | 1360.4 ± 157.9 | 1299.4 ± 152.9 | 1306.2 ± 159.7 | 1297.1 ± 136.4 | 1299.7 ± 148.3 |
 Heart weight, mean ± SD, g | 380.4 ± 96.8 | 376.4 ± 86.7 | 360.8 ± 69.0 | 358.6 ± 76.6* | 365.2 ± 79.3 |
 Braak AD tau stage, mean ± SD | 2.1 ± 1.6 | 3.1 ± 1.3 | 3.1 ± 1.2 | 3.5 ± 1.2* | 3.7 ± 1.3**** |
 Thal amyloid beta phase, mean ± SD | 1.1 ± 1.4 | 1.9 ± 1.5 | 1.6 ± 1.6 | 1.9 ± 1.6 | 1.7 ± 1.7 |
 CERAD amyloid beta stage, mean ± SD | 0.8 ± 1.1 | 1.4 ± 1.2 | 1.2 ± 1.2 | 1.5 ± 1.2 | 1.3 ± 1.2 |
 AD criteria in NIA-AA, High, n (%) | 77 (7.0) | 70 (14.6) | 3 (5.5) | 26 (20.6) | 22 (13.7) |
 Lewy pathology, n (%) | 144 (13.0) | 100 (20.8) | 7 (12.7) | 37 (29.4)# | 48 (29.8)# |
 TDP-43 pathology, n (%) | 25 (2.3) | 21 (4.4) | 2 (3.6) | 16 (12.7)### | 28 (17.4)#### |
 PSP pathology, n (%) | 31 (2.8) | 28 (5.8) | 5 (9.1) | 11 (8.7) | 28 (17.4)#### |