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Table 4 Whole blood half-lives and area under the curve (AUC) for bispecific fusion protein variants

From: ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein

Variant

Half-life (h)

AUC

Fast phase

Slow phase

[125I]I-OX265-F(ab′)2-Bapi

0.50 (0.41–0.59)

10.78 (8.02–14.15)

77.34 (69.85–84.84)

[124I]I-OX2676-F(ab′)2-Bapi

1.22 (0–2.41)

9.17 (7.13–25.96)

82.85 (73.09–92.62)

  1. Data presented as mean (95% confidence intervals)
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Translational Neurodegeneration

ISSN: 2047-9158

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