Fig. 3

A schematic expanding the canonical KEGG pathway for AD, superimposed with proposed specific modulations that may upregulate myelination based on literature search. Targets are color-coded to indicate what action, based on empirical studies covered in this review, may simultaneously (1) encourage at least part of the remyelination cascade and (2) discourage development of AD pathology simultaneously. Green indicates target activation, red indicates inhibition, and yellow indicates conflicting literature on whether activation or inhibition is beneficial. Gray targets are not relevant in the scope of this review