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Fig. 5 | Translational Neurodegeneration

Fig. 5

From: Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson’s disease

Fig. 5

Effects of adenosine A1 receptor (A1R) ligands on α-synuclein (α-syn) expression and folding patterns in in vivo and in vitro studies. a A1R agonist CPA (and adenosine) increases α-syn expression and aggregation in the rat substantia nigra. Nanopore analysis and molecular docking simulations predicted binding of A1R agonist CPA (and adenosine) to the N-terminus of α-syn, leaving the NAC domain intact and able to promote aggregation. b (b1) Adenosine, CPA and 2-aminoindan bind to and stabilize α-syn to adopt a “knot” conformation which has been shown to induce aggregation and neurodegeneration. In contrast (b2), DPCPX and 1-aminoindan bind to both the N- and C-termini of α-syn, which does not promote aggregation and neurodegeneration. Created using BioRender.com

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Translational Neurodegeneration

ISSN: 2047-9158

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