Fig. 1
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs40035-021-00257-y/MediaObjects/40035_2021_257_Fig1_HTML.png)
Heterogeneity of disease progression rates and possible application of a prediction model. a The heterogeneity of disease progression rates in ALS, as shown by ALSFRS-R slopes of each study participant in the three cohorts of this study during the follow-up time. b The application of a prediction model in one patient receiving an efficient treatment. Note that without the use of a prediction model, the treatment effect (difference between the red and green lines) can hardly be differentiated from natural heterogeneity. Eventually, the use of the prediction model (yellow lines) reveals a significant slowdown of disease progression