Fig. 1
From: Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
Physical exercise (PE) reverses the epigenetic clock in the aging brain and in neurodegenerative diseases. The epigenetic clock is associated with aged brain and neurodegenerative diseases, both of which show an accelerated epigenetic age. PE delays the clock by acting on their common pathologies (cognitive dysfunction and neuronal death) and disease-related genes underlying DNAm. AD: APP, BACE1 and PSEN1 in familial AD; APOE in sporadic AD. PD: SNCA in familial PD; PINK1 and Parkin in sporadic PD