Race modifies default mode connectivity in Alzheimer’s disease

Table 4 Factors associated with AD biomarkers (unadjusted p ≤ 0.01) independent of race, adjusting for age, gender, mean framewise displacement, and APOE ε4 allele

Subsystems	Connectivity	Factor	B (95% Confidence Interval)	Unadjusted p	Storey’s q
MTL to MTL	Posterior IPL to Hippocampus	Race	0.019(− 0.29, − 0.05)	0.387
	Posterior IPL to Hippocampus	t-Tau	0.002(0.00, 0.003)	< 0.001	< 0.001
	Posterior IPL to Parahippocampal gyrus	Race	0.32(−0.14, .25)	0.710
	Posterior IPL to Parahippocampal gyrus	Aβ42	0.02 (0.008, 0.40)	0.010	1.000
MTL to midline core	Posterior IPL to Ventromedial prefrontal cortex	Race	−0.05(−0.30, 0.20)	0.675
	Posterior IPL to Ventromedial prefrontal cortex	t-Tau	0.002(0.00, 0.003)	0.001	0.004
	Parahippocampal gyrus to Precuneus	Race	−0.10(−0.30, 0.23)	0.358
	Parahippocampal gyrus to Precuneus	t-Tau	0.002 (0.00, 0.002)	0.008	0.147
MTL to dorsomedial	Temporal Pole to Hippocampus	Race	−0.10(−0.30, 0.10)	0.337
MTL to dorsomedial	Temporal Pole to Hippocampus	t-Tau	0.002(0.00, 0.003)	0.009	0.247

Unadjusted p-values which remain significant after Benjamini-Hochberg step-up correction for multiple comparisons are bolded. Storey’s q-values are also shown with FDR < 10%. MTL Medial Temporal Lobe, IPL inferior parietal lobule

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