Table 1 Sample demographics
Dataset | AD | MCI | Controls | Differences among three groups* |
|---|---|---|---|---|
Proteomic dataset (dataset 1, n = 411) | n = 210 | n = 104 | n = 97 | |
Age (years), mean (SD) | 77 (6.5) | 75 (6.1) | 72 (6.6) | P = 1.13e-08 |
Gender (female/male) | 133/77 | 59/45 | 56/41 | P = 0.4431 |
APOE ε4 allele (absence/presence) | 89/115 | 58/46 | 65/32 | P = 5.349e-04 |
ROD per year, mean (SD)a | −1.49 (1.26) (n = 127) | NA | NA | NA |
Brain imaging | n = 53 | n = 0 | n = 67 | |
Whole brain volume, mean (SD)b | 0.66 (0.073) | NA | 0.69 (0.043) | P = 0.003184 |
Left hippocampal volume, mean (SD) b | 0.0018 (0.00037) | NA | 0.0024 (0.00031) | P = 7.717e-15 |
Right hippocampal volume, mean (SD) b | 0.0019 (0.00041) | NA | 0.0025 (0.00031) | P = 3.535e-13 |
Left entorhinal cortical volume, mean (SD) b | 0.00095 (0.00038) | NA | 0.0012 (0.00024) | P = 1.433e-05 |
Right entorhinal cortical volume, mean (SD) b | 0.00092 (0.00034) | NA | 0.0013 (0.00028) | P = 3.562e-08 |
Lipidomic dataset (dataset 2, n = 415) | n = 185 | n = 40 | n = 190 | |
Age (years), mean (SD) | 77 (6.9) | 75 (6.3) | 79 (5.5) | P = 6.77e-05 |
Gender (female/male) | 114/71 | 20/20 | 116/74 | P = 0.377 |
APOE ε4 allele (absence/presence) | 73/110 | 22/15 | 138/51 | P = 8.725e-10 |
ROD per year, mean (SD)a | −1.50 (1.22) (n =144) | NA | NA | NA |
Brain imaging results | n = 57 | n = 8 | n = 67 | |
Whole brain volume, mean (SD) b | 0.66 (0.071) | 0.71 (0.041) | 0.69 (0.098) | P = 0.0006595 |
Left hippocampal volume, mean (SD) b | 0.0018 (0.00038) | 0.0021 (0.00031) | 0.0024 (0.00060) | P = 1.763e-15 |
Right hippocampal volume, mean (SD) b | 0.0018 (0.00043) | 0.0022 (0.00032) | 0.0024 (0.00062) | P = 2.572e-13 |
Left entorhinal cortical volume, mean (SD) b | 0.00093 (0.00038) | 0.0012 (0.00024) | 0.0012 (0.00030) | P = 2.782e-06 |
Right entorhinal cortical volume, mean (SD) b | 0.00090 (0.00033) | 0.0011 (0.00028) | 0.0013 (0.00027) | P = 4.114e-09 |
Proteomic validation dataset (dataset 3, n = 249) | n = 94 | n = 55 | n = 100 | |
Age (years), mean (SD) | 83 (6.2) | 77 (4.5) | 79 (7.0) | P = 2.02e-12 |
Gender (female/male) | 72/22 | 35/20 | 47/53 | P = 1.185e-04 |
APOE ε4 allele (absence/presence) | 40/50 | 30/10 | 79/20 | P = 8.204e-07 |