Fig. 1
Identification and quantification of neuronal-derived exosomes (NDEs). a. Electron microscopic image showing that NDEs were successfully collected. b. Western blot showing that exosomal positive marker L1CAM, CD63, Tsg101 was highly expressed in exosomal pellet but not detected in supernatants. c.NTA analysis of concentration and diameter in NDEs. d.ELISA test of CD63 level in NDEs indicating that the number of exosomes was not significantly different in three groups. e. ELISA test of Aβ1–42 level in NDEs showing that Aβ1–42 was elevated in MCI and AD dementia groups. **: p < 0.01; ****: p < 0.001. f. ELISA test of Aβ1–40 level in NDEs indicating that Aβ1–40 was not significantly different in three groups. g. ELISA test of Aβ1–42/Aβ1–40 level in NDEs indicating that Aβ1–42/Aβ1–40 level was elevated in MCI and AD dementia groups. ****: p < 0.001