Characteristics | rs4633 C > T; rs4680 G > A | rs6269 A > G; rs4818 C > G | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
CC/GG | CT/GA | TT/AA | Rare | P | AA/CC | AG/CG | GG/GG | Rare | P | |
n | 78 | 55 | 8 | 2 | 61 | 64 | 13 | 5 | ||
H&Y stageb | 2.0 ± 1.5 | 2.0 ± 1.0 | 2.8 ± 0.5 | 2.50 ± 1.0 | 0.03* | 2.5 ± 1.0 | 2.0 ± 1.0 | 2.0 ± 0.8 | 2.0 ± 1.5 | 0.12 |
Age onset (years)a | 60.7 ± 9.2 | 57.5 ± 9.5 | 56.8 ± 5.7 | 58.0 ± 5.7 | 0.03* | 59.4 ± 9.6 | 58.6 ± 8.8 | 60.8 ± 10.9 | 60.8 ± 5.1 | 0.71 |
Disease duration (years)b | 6.0 ± 4.0 | 6.0 ± 6.0 | 8.5 ± 9.5 | 9.0 ± 4.0 | 0.02* | 6.0 ± 5.5 | 6.0 ± 5.3 | 8.0 ± 8.5 | 4.0 ± 3.5 | 0.67 |
LED (mg)a | 386.2 ± 287.5 | 494.0 ± 360.7 | 692.4 ± 344.8 | 675.0 ± 35.4 | 0.01* | 479.0 ± 401.5 | 431.8 ± 241.4 | 416.4 ± 342.2 | 448.8 ± 327.4 | 0.67 |
Wearing-off (yes, %) | 18 (23.1) | 19 (34.6) | 5 (62.5) | 1(50.0) | 0.02* | 20 (32.8) | 17 (26. 6) | 5 (38.5) | 1 (20.0) | 0.87 |
Dyskinesia (yes, %) | 7 (9.0) | 9 (16.4) | 2 (25.0) | 0 | 0.07 | 8 (13.1) | 7 (10.9) | 3 (23.1) | 0 | 0.52 |
UPDRS Part I scoreb | 2.0 ± 3.0 | 3.0 ± 3.0 | 2.0 ± 3.5 | 3.0 ± 0.0 | 0.98 | 2.0 ± 4.0 | 2.0 ± 3.0 | 3.0 ± 3.0 | 3.0 ± 5.5 | 0.50 |
UPDRS Part II scoreb | 8.5 ± 9.0 | 8.0 ± 6.0 | 13.0 ± 7.8 | 13.5 ± 17.0 | 0.03* | 8.0 ± 7.0 | 8.5 ± 7.0 | 9.0 ± 7.5 | 10.0 ± 13.0 | 0.77 |
UPDRS Part III scorea | 25.9 ± 11.9 | 21.9 ± 11.7 | 31.0 ± 11.9 | 32.0 ± 21.2 | 0.08 | 25.1 ± 12.3 | 24.5 ± 12.2 | 26.2 ± 10.3 | 19.4 ± 14. 9 | 0.83 |
UPDRS Part IV scoreb | 3.0 ± 2.0 | 2.0 ± 3. 0 | 4.5 ± 4.0 | 4.0 ± 2.0 | 0.24 | 3.0 ± 3.5 | 2.0 ± 2.8 | 3.0 ± 2.0 | 2.0 ± 4.0 | 0.78 |
UPDRS total scorea | 41.0 ± 17.4 | 36.4 ± 16.6 | 52.0 ± 19.7 | 52.5 ± 34.7 | 0.047* | 40.5 ± 18.6 | 39.1 ± 17.2 | 44.1 ± 15.5 | 34.6 ± 20.4 | 0.86 |
NMS scoreb | 6.0 ± 6.0 | 6.0 ± 4.0 | 6.5 ± 10.8 | 6.5 ± 9.0 | 0.85 | 7.0 ± 6.5 | 6.0 ± 5.75 | 6.0 ± 6.0 | 9.0 ± 11.0 | 0.46 |
HAMA scoreb | 4.0 ± 6.0 | 5.0 ± 5.0 | 4.5 ± 13.3 | 3.0 ± 4.0 | 0.29 | 5.0 ± 6.0 | 4.0 ± 4.0 | 6.0 ± 6.0 | 8.0 ± 12.5 | 0.20 |
HAMD scoreb | 2.0 ± 5.0 | 4.0 ± 4.0 | 3.0 ± 6.5 | 2.0 ± 4.0 | 0.56 | 2.0 ± 6.5 | 3.0 ± 4.0 | 2.0 ± 2.0 | 7.0 ± 7.5 | 0.86 |
MMSE scoreb | 28.0 ± 3.0 | 28.0 ± 3.0 | 27.5 ± 3.0 | 26.5 ± 3.0 | 0.72 | 28.0 ± 3.0 | 28.0 ± 3.0 | 28.0 ± 3.0 | 29.0 ± 2.0 | 0.37 |