Figure 3
Effect of 17-AAG on neurofibrillary tangles in JNPL3 mice. AT8 immunostaining (brown) revealing NFTs in the medulla of JNPL3 mice treated with 17-AAG. Haematoxylin counterstain (blue) indicates cell nuclei. 40x magnification. Left: 0 mg/kg 17-AAG. Middle: 5 mg/kg 17-AAG. Right: 25 mg/kg 17-AAG. Top two rows: Male mice. Bottom two rows: Female mice.