Asiaticoside, a trisaccaride triterpene induces biochemical and molecular variations in brain of mice with parkinsonism

Table 1 Effect of As on the activities of Na ⁺ K ⁺ ATPase, Mg ²⁺ ATPase, Ca ²⁺ ATPase in the striatal and midbrain tissue of control and experimental mice

	Striatal tissue				Midbrain
Particulars	Group I (Control)	Group II (MPTP induced)	Group III (MPTP induced + AS Treated)	Group IV (AS Control)	Group I (Control)	Group II (MPTP induced)	Group III (MPTP induced + AS Treated)	Group IV (AS Control)
Na⁺ K ⁺ ATPase	0.33 ± 0.01	0.25 ± 0.03^a*	0.33 ± 0.04^b*	0.34 ± 0.06^NS	0.34 ± 0.13	0.23 ± 0.03^a*	0.34 ± 0.02^b*	0.34 ± 0.02^NS
Mg²⁺ ATPase	0.44 ± 0.03	0.32 ± 0.02^a*	0.35 ± 0.03^b*	0.44 ± 0.04^NS	0.44 ± 0.03	0.35 ± 0.06^a*	0.43 ± 0.02^b*	0.45 ± 0.02^NS
Ca²⁺ ATPase	0.54 ± 0.06	0.34 ± 0.04^a*	0.35 ± 0.03^b*	0.44 ± 0.08^NS	0.54 ± 0.08	0.33 ± 0.01^a*	0.46 ± 0.01^b*	0.56 ± 0.02^NS

Na⁺ K ⁺, Mg²⁺, Ca²⁺ ATPase = μmoles of Pi liberated/min/mg protein. Each value expressed as mean ± S.D for six mice (n = 6) in each group. Statistically significance at *p < 0.05; a group I vs group II, b group II vs group III and (NS) non-significant group IV vs group I.

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