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Figure 1 | Translational Neurodegeneration

Figure 1

From: Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation

Figure 1

α-Synuclein immunohistochemistry in PD. Although both sporadic cases and those with A53T α-synuclein mutations had severe neuronal loss in the substantia nigra, substantially more α-synuclein positive neurites and dots were seen in the A53T cases (A) compared with sporadic PD (B). As expected, there were more α-synuclein-immunopositive Lewy body and astrocytes in the cortex of end-stage (C) versus earlier stages of PD (D).

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Translational Neurodegeneration

ISSN: 2047-9158

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