From: Current advances in using neurotrophic factors to treat neurodegenerative disorders
 | Neurotrophic factor | Target neurons | Current status |
---|---|---|---|
ALS | NGF and BDNF | Motor neurons | Recruiting for Phase 1 and Phase 2 |
Parkinson’s disease | GDNF/neurturin | Striatal neurons | Some Phase 1 complete, ongoing in Phase 1 and Phase 2 |
Huntington’s disease | BDNF | Striatal neurons | Pre-clinical |
Alzheimer’s disease | NGF and BDNF | Cholinergic neurons, entorhinal neurons | Ongoing in Phase 1 |
Down Syndrome | NGF | Cholinergic neurons | Pre-clinical |
Spinal Cord Injury | BDNF and NT-3 | Site of injury | Pre-clinical |
Obesity | BDNF | Hypothalamus | Pre-clinical |
Lysosomal storage disorders | BDNF | Various in CNS | Pre-clinical |
Sensory neuropathies | NGF | Sensory and sympathetic neurons | Phase 2 completed |
Supranuclear Palsy | GDNF | Various in CNS | Phase 2 completed |